human HFE2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HFE2.
shADV-210993
Ad-h-HFE2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HFE2 (hemochromatosis type 2 (juvenile)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HFE2A; HJV; JH; RGMC
Description (Vector)
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Gene ID
148738
Gene Name (Vector)
hemochromatosis type 2 (juvenile)
Gene Symbol
HFE2
HGNC ID
HGNC:4887
ORF Size (aa)
942
RefSeq ID
NM_202004
RefSeq Synonyms
NM_213653, NM_213652, NM_202004, NM_145277, NM_001316767, BC085604, BC017926,
Species
human
UniGene ID
Hs.632436
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.