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human GRK6 shRNA silencing Adenovirus

Name 
Ad-h-GRK6-shRNA
Cat No 
shADV-210541
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GRK6.

shADV-210541
Ad-h-GRK6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GRK6 (G protein-coupled receptor kinase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; GPRK6
Description (eCommerce)
G protein-coupled receptor kinase 6 (GRK6) is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation [taken from NCBI Entrez Gene (Gene ID: 2870)].
Description (Vector)
GRK6 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
Gene ID
2870
Gene Name (eCommerce)
G protein-coupled receptor kinase 6
Gene Name (Vector)
G protein-coupled receptor kinase 6
Gene Symbol
GRK6
HGNC ID
HGNC:4545
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1770
ORF Size (bp)
1770 bp
Protein Name (eCommerce)
G protein-coupled receptor kinase 6
RefSeq ID
NM_002082
RefSeq Synonyms
NM_002082, NM_001004106, NM_001004105, BC017272, BC009277,
Research Areas
Cardiology,Cardiovascular,EPO Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,Signal Transduction,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cardiovascular,cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
G protein-coupled receptor kinase 6 (GRK6) is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation [taken from NCBI Entrez Gene (Gene ID: 2870)].
UniGene ID
Hs.235116
UniProt ID (eCommerce)
P43250

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.