human GSTM3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GSTM3.
shAAV-210607
AAV-h-GSTM3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GSTM3 (glutathione S-transferase mu 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GST5; GSTB; GSTM3-3; GTM3
Description (Vector)
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
Gene ID
2947
Gene Name (Vector)
glutathione S-transferase mu 3
Gene Symbol
GSTM3
HGNC ID
HGNC:4635
ORF Size (aa)
678
ORF Size (bp)
678 bp
RefSeq ID
NM_000849
RefSeq Synonyms
NM_000849, BC008790, BC000088,
Species
human
UniGene ID
Hs.2006
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.