mouse GRK6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Grk6.
shAAV-260783
AAV-m-GRK6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Grk6 (G protein-coupled receptor kinase 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Gprk6
Description (Vector)
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Gene ID
26385
Gene Name (Vector)
G protein-coupled receptor kinase 6
Gene Symbol
Grk6
ORF Size (aa)
1770
ORF Size (bp)
1770 bp
RefSeq ID
NM_011938
RefSeq Synonyms
NM_011938, NM_001286066, NM_001286065, NM_001286064, NM_001286063, NM_001112711, NM_001038018, BC075719,
Species
mouse
UniGene ID
Mm.10193
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.