human GRIA2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GRIA2.
shADV-210506
Ad-h-GRIA2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GluA2; GluR-K2; GLUR2; GLURB; HBGR2
Description (Vector)
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
Gene ID
2891
Gene Name (Vector)
glutamate ionotropic receptor AMPA type subunit 2
Gene Symbol
GRIA2
HGNC ID
HGNC:4572
ORF Size (aa)
2652
ORF Size (bp)
2652 bp
RefSeq ID
NM_000826
RefSeq Synonyms
NM_001083620, NM_001083619, NM_000826, BC010574,
Species
human
UniGene ID
Hs.32763
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.