human L2HGDH Over-expression AAV

Name
AAV-h-L2HGDH

Cat No
AAV-213624

Availability
4-5 weeks

This is an AAV expressing Human L2HGDH.

AAV-213624

AAV-h-L2HGDH

Ready-to-use AAV expressing Human L2HGDH (L-2-hydroxyglutarate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C14orf160; L2HGA

Description (Vector)

L2HGDH encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.

Gene ID

79944

Gene Name (Vector)

L-2-hydroxyglutarate dehydrogenase

Gene Symbol

L2HGDH

HGNC ID

HGNC:20499

ORF Size (aa)

1326

ORF Size (bp)

1326 bp

RefSeq ID

NM_024884

RefSeq Synonyms

NM_024884, BC006117,

Species

human

UniGene ID

Hs.256034

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.