human KLHL12 Over-expression AAV

Name 
AAV-h-KLHL12
Cat No 
AAV-213228
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KLHL12.

AAV-213228
AAV-h-KLHL12

Ready-to-use AAV expressing Human KLHL12 (kelch like family member 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C3IP1; CUL3-interacting protein 1; DKIR; DKIR homolog; hDKIR; kelch-like protein 12; kelch-like protein C3IP1
Description (eCommerce)
Kelch-like protein 12 (KLHL12) serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. KLHL12 negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53G59].
Gene ID
59349
Gene Name (eCommerce)
kelch like family member 12
Gene Name (Vector)
kelch like family member 12
Gene Symbol
KLHL12
HGNC ID
HGNC:19360
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1707
ORF Size (bp)
1707 bp
Protein Name (eCommerce)
Kelch-like protein 12
RefSeq ID
NM_021633
RefSeq Synonyms
NM_021633, NM_001303109, NM_001303051, BC004175, BC003183,
Research Areas
Golgi Apparatus,Signal Transduction,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Kelch-like protein 12 (KLHL12) serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. KLHL12 negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53G59].
UniGene ID
Hs.706793
UniProt ID (eCommerce)
Q53G59

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.