human CLDN16 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CLDN16.
shADV-205368
Ad-h-CLDN16-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CLDN16 (claudin 16). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HOMG3; PCLN1
Description (Vector)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.
Gene ID
10686
Gene Name (Vector)
claudin 16
Gene Symbol
CLDN16
HGNC ID
HGNC:2037
ORF Size (aa)
918
RefSeq ID
NM_006580
RefSeq Synonyms
NM_006580, BC069777, BC069759, BC069682, BC069662,
Species
human
UniGene ID
Hs.251391
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.