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human CDC20 shRNA silencing Adenovirus

Name 
Ad-h-CDC20-shRNA
Cat No 
shADV-204721
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CDC20.

shADV-204721
Ad-h-CDC20-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CDC20 (cell division cycle 20). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bA276H19.3; CDC20 cell division cycle 20 homolog; CDC20A; cell division cycle 20 homolog; cell division cycle protein 20 homolog; p55CDC
Description (eCommerce)
CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.
Description (Vector)
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
Gene ID
991
Gene Name (eCommerce)
cell division cycle 20
Gene Name (Vector)
cell division cycle 20
Gene Symbol
CDC20
HGNC ID
HGNC:1723
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
Protein Name (eCommerce)
Cell division cycle protein 20 homolog
RefSeq ID
NM_001255
RefSeq Synonyms
NM_001255, BC110321, BC031294, BC024257, BC015998, BC013303, BC012827, BC012803, BC010044, BC009426, BC009425, BC006272, BC001088, BC000624,
Research Areas
Antigen Processing and Presentation,Cancer,Cell Cycle,Cell Division,Cytoskeleton,Host-Virus Interactions,Immunology,Meiosis,Neurobiology,Neurodevelopment,Neurogenesis,PLK1 Signaling,Signal Transduction,Ubiquitination,Viral Carcinogenesis
Research Areas (Faceted)
cancer,signal_transduction,immunology,cell_biology,cell_cycle,infectious_disease,immunology,cell_biology,cell_cycle,neurobiology,developmental_biology,signal_transduction,genetics,cancer,infectious_disease
Species
human
Target Sentence
CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.
UniGene ID
Hs.524947
UniProt ID (eCommerce)
Q12834

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.