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mouse CDC20 shRNA silencing Adenovirus

Name 
Ad-m-CDC20-shRNA
Cat No 
shADV-255076
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Cdc20.

shADV-255076
Ad-m-CDC20-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cdc20 (cell division cycle 20). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2310042N09Rik; C87100; p55CDC
Description (Vector)
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Gene ID
107995
Gene Name (Vector)
cell division cycle 20
Gene Symbol
Cdc20
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
RefSeq ID
NM_023223
RefSeq Synonyms
NM_023223, BC003215,
Species
mouse
UniGene ID
Mm.396441

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.