human C16ORF57 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human USB1.
shADV-202744
Ad-h-C16ORF57-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human USB1 (U6 snRNA biogenesis phosphodiesterase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C16orf57; hUsb1; HVSL1; Mpn1; PN
Description (Vector)
USB1 encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
79650
Gene Name (Vector)
U6 snRNA biogenesis phosphodiesterase 1
Gene Symbol
USB1
HGNC ID
HGNC:25792
ORF Size (aa)
798
RefSeq ID
NM_024598
RefSeq Synonyms
NM_024598, NM_001330569, NM_001330568, NM_001204911, NM_001195302, BC021554, BC010099, BC007774, BC006291, BC004415,
Species
human
UniGene ID
Hs.588873
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.