rat PRPF19 shRNA silencing AAV

Name
AAV-r-PRPF19-shRNA

Cat No
shAAV-294777

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Prpf19.

shAAV-294777

AAV-r-PRPF19-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Prpf19 (pre-mRNA processing factor 19). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Prp19

Description (Vector)

Plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.

Gene ID

246216

Gene Name (Vector)

pre-mRNA processing factor 19

Gene Symbol

Prpf19

ORF Size (aa)

1515

ORF Size (bp)

1515 bp

RefSeq ID

NM_139333

RefSeq Synonyms

NM_139333, BC107669,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.