mouse TOPORS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Topors.
shAAV-274821
AAV-m-TOPORS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Topors (topoisomerase I binding, arginine/serine-rich). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW105885; LUN; p53BP3/LUN; TP53BPL
Description (Vector)
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Gene ID
106021
Gene Name (Vector)
topoisomerase I binding, arginine/serine-rich
Gene Symbol
Topors
ORF Size (aa)
3102
ORF Size (bp)
3102 bp
RefSeq ID
NM_134097
RefSeq Synonyms
NM_134097, BC040797,
Species
mouse
UniGene ID
Mm.251548
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.