human TOPORS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TOPORS.
shAAV-226210
AAV-h-TOPORS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TOPORS (TOP1 binding arginine/serine rich protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E3 ubiquitin-protein ligase Topors; LUN; p53-binding protein 3; P53BP3; RING-type E3 ubiquitin transferase Topors; RP31; SUMO1-protein E3 ligase Topors; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Topoisomerase I-binding arginine/serine-rich protein; topoisomerase I-binding RING finger protein; TP53BPL; tumor suppressor p53-binding protein 3
Description (eCommerce)
TOPORS (topoisomerase I-binding RS protein) was identified in a a yeast two-hybrid screen for proteins that bind the N-terminus of topoisomerase I. TOPORS contains a RING-type zinc-finger domain and an RS-rich region. TOPORS has been found to possess both ubiquitin and SUMO-1 E3 ligase activity. It can ubiquitinate and sumoylate p53 and may possibly function as a tumor suppressor. Defects in TOPORS are the cause of retinitis pigmentosa type 31.
Description (Vector)
TOPORS encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
Gene ID
10210
Gene Name (eCommerce)
TOP1 binding arginine/serine rich protein
Gene Name (Vector)
TOP1 binding arginine/serine rich protein
Gene Symbol
TOPORS
HGNC ID
HGNC:21653
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3138
ORF Size (bp)
3138 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase Topors
RefSeq ID
NM_005802
RefSeq Synonyms
NM_005802, NM_001195622, BC060884,
Research Areas
Apoptosis,Cell Cycle,DNA Damage/Repair,Immunology,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,immunology
Species
human
Target Sentence
TOPORS (topoisomerase I-binding RS protein) was identified in a a yeast two-hybrid screen for proteins that bind the N-terminus of topoisomerase I. TOPORS contains a RING-type zinc-finger domain and an RS-rich region. TOPORS has been found to possess both ubiquitin and SUMO-1 E3 ligase activity. It can ubiquitinate and sumoylate p53 and may possibly function as a tumor suppressor. Defects in TOPORS are the cause of retinitis pigmentosa type 31.
UniGene ID
Hs.711159
UniProt ID (eCommerce)
Q9NS56
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.