human GMDS Over-expression AAV

Name 
AAV-h-GMDS
Cat No 
AAV-210033
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GMDS.

AAV-210033
AAV-h-GMDS

Ready-to-use AAV expressing Human GMDS (GDP-mannose 4,6-dehydratase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GDP-D-mannose dehydratase; GDP-mannose 4,6 dehydratase; GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1
Description (eCommerce)
GDP-mannose 4,6-dehydratase (GMDS) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020) [taken from NCBI Entrez Gene (Gene ID: 2762)].
Description (Vector)
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).(supplied by OMIM, Aug 2009)
Gene ID
2762
Gene Name (eCommerce)
GDP-mannose 4,6-dehydratase
Gene Name (Vector)
GDP-mannose 4,6-dehydratase
Gene Symbol
GMDS
HGNC ID
HGNC:4369
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1119
ORF Size (bp)
1119 bp
Protein Name (eCommerce)
GDP-mannose 4,6 dehydratase
RefSeq ID
NM_001500
RefSeq Synonyms
NM_001500, NM_001253846, BC000117,
Research Areas
Metabolism/Metabolic Process,Notch Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,signal_transduction
Species
human
Target Sentence
GDP-mannose 4,6-dehydratase (GMDS) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020) [taken from NCBI Entrez Gene (Gene ID: 2762)].
UniGene ID
Hs.660919
UniProt ID (eCommerce)
O60547

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.