human GMDS shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GMDS.
shADV-210033
Ad-h-GMDS-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GMDS (GDP-mannose 4,6-dehydratase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GDP-D-mannose dehydratase; GDP-mannose 4,6 dehydratase; GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1
Description (eCommerce)
GDP-mannose 4,6-dehydratase (GMDS) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020) [taken from NCBI Entrez Gene (Gene ID: 2762)].
Description (Vector)
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).(supplied by OMIM, Aug 2009)
Gene ID
2762
Gene Name (eCommerce)
GDP-mannose 4,6-dehydratase
Gene Name (Vector)
GDP-mannose 4,6-dehydratase
Gene Symbol
GMDS
HGNC ID
HGNC:4369
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1119
ORF Size (bp)
1119 bp
Protein Name (eCommerce)
GDP-mannose 4,6 dehydratase
RefSeq ID
NM_001500
RefSeq Synonyms
NM_001500, NM_001253846, BC000117,
Research Areas
Metabolism/Metabolic Process,Notch Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,signal_transduction
Species
human
Target Sentence
GDP-mannose 4,6-dehydratase (GMDS) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020) [taken from NCBI Entrez Gene (Gene ID: 2762)].
UniGene ID
Hs.660919
UniProt ID (eCommerce)
O60547
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.