mouse GRIA2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Gria2.
shAAV-260750
AAV-m-GRIA2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Gria2 (glutamate receptor, ionotropic, AMPA2 (alpha 2)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GluA2; Glur-2; GluR-B; Glur2
Description (Vector)
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
Gene ID
14800
Gene Name (Vector)
glutamate receptor, ionotropic, AMPA2 (alpha 2)
Gene Symbol
Gria2
ORF Size (aa)
1485
ORF Size (bp)
1485 bp
RefSeq ID
NM_013540
RefSeq Synonyms
NM_013540, NM_001083806, NM_001039195, BC048248,
Species
mouse
UniGene ID
Mm.220224
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.