human GRIA2 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-210506
Availability:
5-8 weeks
Name:
Ad-h-GRIA2-shRNA
This is an Adenovirus expressing shRNA for silencing of Human GRIA2.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- GRIA2
- Gene Name
- glutamate ionotropic receptor AMPA type subunit 2
- Gene ID
- 2891
- Gene Synonyms
- GluA2; GluR-K2; GLUR2; GLURB; HBGR2
- ORF Size
- 2652 bp
- RefSeq#
- NM_000826
- Gene Description
- Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
- UniGene ID
- Hs.32763
- HGNC ID
- HGNC:4572
Related Products
Product | Cat No. |
---|---|
AAV-h-GRIA2 | AAV-210506 |
AAV-m-GRIA2 | AAV-260750 |
Ad-h-GRIA2 | ADV-210506 |
Ad-m-GRIA2 | ADV-260750 |
AAV-h-GRIA2-shRNA | shAAV-210506 |
AAV-m-GRIA2-shRNA | shAAV-260750 |
Ad-m-GRIA2-shRNA | shADV-260750 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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