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mouse GIYD2 shRNA silencing AAV

Name 
AAV-m-GIYD2-shRNA
Cat No 
shAAV-260122
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Slx1b.

shAAV-260122
AAV-m-GIYD2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Slx1b (SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1110030E23Rik; 2410170E21Rik; 4833422P03Rik; AI853643; Giyd1; Giyd2
Description (Vector)
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
Gene ID
75764
Gene Name (Vector)
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Gene Symbol
Slx1b
ORF Size (aa)
813
ORF Size (bp)
813 bp
RefSeq ID
NM_029420
RefSeq Synonyms
NM_029420, BC145688,
Species
mouse
UniGene ID
Mm.280573

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.