mouse FPGS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Fpgs.
shAAV-259611
AAV-m-FPGS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Fpgs (folylpolyglutamyl synthetase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA408187
Description (Vector)
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Gene ID
14287
Gene Name (Vector)
folylpolyglutamyl synthetase
Gene Symbol
Fpgs
ORF Size (aa)
1638
ORF Size (bp)
1638 bp
RefSeq ID
NM_010236
RefSeq Synonyms
NM_010236, BC005484,
Species
mouse
UniGene ID
Mm.3830
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.