human FSCN1 Over-expression AAV

Name 
AAV-h-FSCN1
Cat No 
AAV-209334
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human FSCN1.

AAV-209334
AAV-h-FSCN1

Ready-to-use AAV expressing Human FSCN1 (fascin actin-bundling protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
55 kDa actin-bundling protein; epididymis secretory sperm binding protein; FAN1; fascin; fascin homolog 1, actin-bundling protein; HSN; p55; singed-like (fascin homolog, sea urchin); Singed-like protein; SNL
Description (eCommerce)
Fascin organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Fascin plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. It is important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16658].
Description (Vector)
FSCN1 encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
Gene ID
6624
Gene Name (eCommerce)
fascin actin-bundling protein 1
Gene Name (Vector)
fascin actin-bundling protein 1
Gene Symbol
FSCN1
HGNC ID
HGNC:11148
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
Protein Name (eCommerce)
Fascin
RefSeq ID
NM_003088
RefSeq Synonyms
NM_003088, BC007988, BC007948, BC006304, BC000521,
Research Areas
Cancer,Cytoskeleton
Research Areas (Faceted)
cancer,cell_biology
Species
human
Target Sentence
Fascin organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Fascin plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. It is important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16658].
UniGene ID
Hs.705741
UniProt ID (eCommerce)
Q16658

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.