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human FSCN1 shRNA silencing AAV

Name 
AAV-h-FSCN1-shRNA
Cat No 
shAAV-209334
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FSCN1.

shAAV-209334
AAV-h-FSCN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FSCN1 (fascin actin-bundling protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
55 kDa actin-bundling protein; epididymis secretory sperm binding protein; FAN1; fascin; fascin homolog 1, actin-bundling protein; HSN; p55; singed-like (fascin homolog, sea urchin); Singed-like protein; SNL
Description (eCommerce)
Fascin organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Fascin plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. It is important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16658].
Description (Vector)
FSCN1 encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
Gene ID
6624
Gene Name (eCommerce)
fascin actin-bundling protein 1
Gene Name (Vector)
fascin actin-bundling protein 1
Gene Symbol
FSCN1
HGNC ID
HGNC:11148
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
Protein Name (eCommerce)
Fascin
RefSeq ID
NM_003088
RefSeq Synonyms
NM_003088, BC007988, BC007948, BC006304, BC000521,
Research Areas
Cancer,Cytoskeleton
Research Areas (Faceted)
cancer,cell_biology
Species
human
Target Sentence
Fascin organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Fascin plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. It is important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16658].
UniGene ID
Hs.705741
UniProt ID (eCommerce)
Q16658

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.