mouse SKA1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ska1.
shAAV-250887
AAV-m-SKA1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ska1 (spindle and kinetochore associated complex subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810433K01Rik; AV117428
Description (Vector)
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
Gene ID
66468
Gene Name (Vector)
spindle and kinetochore associated complex subunit 1
Gene Symbol
Ska1
ORF Size (aa)
765
ORF Size (bp)
765 bp
RefSeq ID
NM_025581
RefSeq Synonyms
NM_025581, NM_001164355, BC019940,
Species
mouse
UniGene ID
Mm.283406
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.