human TRPS1 shRNA silencing AAV

Name
AAV-h-TRPS1-shRNA

Cat No
shAAV-226559

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TRPS1.

shAAV-226559

AAV-h-TRPS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRPS1 (transcriptional repressor GATA binding 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

50

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GC79; LGCR; trichorhinophalangeal syndrome I; tricho-rhino-phalangeal syndrome type I protein; zinc finger protein GC79; zinc finger transcription factor Trps1

Description (eCommerce)

Tricho-rhino-phalangeal syndrome type I protein (TRPS1) is a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of TRPS1 to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in the TRPS1 gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III [taken from NCBI Entrez Gene (Gene ID: 7227)].

Description (Vector)

TRPS1 encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III.

Gene ID

7227

Gene Name (eCommerce)

transcriptional repressor GATA binding 1

Gene Name (Vector)

transcriptional repressor GATA binding 1

Gene Symbol

TRPS1

HGNC ID

HGNC:12340

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2562

ORF Size (bp)

2562 bp

Protein Name (eCommerce)

Zinc finger transcription factor Trps1

RefSeq ID

NM_014112

RefSeq Synonyms

NM_014112, NM_001330599, NM_001282903, NM_001282902, BC125020,

Research Areas

Transcription Factor/Regulator,Zinc-finger

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

Tricho-rhino-phalangeal syndrome type I protein (TRPS1) is a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of TRPS1 to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in the TRPS1 gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III [taken from NCBI Entrez Gene (Gene ID: 7227)].

UniGene ID

Hs.657018

UniProt ID (eCommerce)

Q9UHF7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.