human TLK1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TLK1.
shAAV-225572
AAV-h-TLK1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TLK1 (tousled like kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PKU-beta; serine threonine protein kinase; serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; Tousled-like kinase 1
Description (eCommerce)
Tousled-like kinase 1 (TLK1) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The histone chaperone, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2. TLK1 has also been shown to be important for cell cycle progression and proper chromosome segregation.
Description (Vector)
TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
9874
Gene Name (eCommerce)
tousled like kinase 1
Gene Name (Vector)
tousled like kinase 1
Gene Symbol
TLK1
HGNC ID
HGNC:11841
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2301
ORF Size (bp)
2301 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase tousled-like 1
RefSeq ID
NM_012290
RefSeq Synonyms
NM_012290, NM_001136555, NM_001136554, BC032657,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,Kinase/Phosphatase,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Tousled-like kinase 1 (TLK1) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of plant organs. There are two tousled-like kinases in humans, TLK1 and TLK2, that can dimerize or heterodimerize for function and can be phosphorylated and inactivated by Chk1 in response to DNA damage. The histone chaperone, Asf1 (anti-silencing function 1), has been reported as a substrate for both TLK1 and TLK2. TLK1 has also been shown to be important for cell cycle progression and proper chromosome segregation.
UniGene ID
Hs.596942
UniProt ID (eCommerce)
Q9UKI8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.