human PLAU shRNA silencing AAV

Name
AAV-h-PLAU-shRNA

Cat No
shAAV-219110

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PLAU.

shAAV-219110

AAV-h-PLAU-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLAU (plasminogen activator, urokinase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATF; BDPLT5; QPD; u-PA; UPA; URK

Description (Vector)

PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

5328

Gene Name (Vector)

plasminogen activator, urokinase

Gene Symbol

PLAU

HGNC ID

HGNC:9052

ORF Size (aa)

1296

ORF Size (bp)

1296 bp

RefSeq ID

NM_002658

RefSeq Synonyms

NM_002658, NM_001319191, NM_001145031, BC013575,

Species

human

UniGene ID

Hs.77274

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.