human PLAU shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PLAU.
shADV-219110
Ad-h-PLAU-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PLAU (plasminogen activator, urokinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATF; BDPLT5; QPD; u-PA; UPA; URK
Description (Vector)
PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5328
Gene Name (Vector)
plasminogen activator, urokinase
Gene Symbol
PLAU
HGNC ID
HGNC:9052
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
RefSeq ID
NM_002658
RefSeq Synonyms
NM_002658, NM_001319191, NM_001145031, BC013575,
Species
human
UniGene ID
Hs.77274
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.