human PIK3CB shRNA silencing AAV

Name
AAV-h-PIK3CB-shRNA

Cat No
shAAV-218947

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PIK3CB.

shAAV-218947

AAV-h-PIK3CB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

P110BETA; PI3K; PI3KBETA; PIK3C1

Description (Vector)

PIK3CB encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants.

Gene ID

5291

Gene Name (Vector)

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

Gene Symbol

PIK3CB

HGNC ID

HGNC:8976

ORF Size (aa)

3213

ORF Size (bp)

3213 bp

RefSeq ID

NM_006219

RefSeq Synonyms

NM_006219, NM_001256045, BC114432,

Species

human

UniGene ID

Hs.239818

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.