human ELK1 Over-expression AAV

Name 
AAV-h-ELK1
Cat No 
AAV-207840
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ELK1.

AAV-207840
AAV-h-ELK1

Ready-to-use AAV expressing Human ELK1 (ELK1, ETS transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1) oncogene
Description (eCommerce)
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade [taken from NCBI Entrez Gene (Gene ID: 2002)].
Description (Vector)
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. ELK1 produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
Gene ID
2002
Gene Name (eCommerce)
ELK1, ETS transcription factor
Gene Name (Vector)
ELK1, ETS transcription factor
Gene Symbol
ELK1
HGNC ID
HGNC:3321
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1287
ORF Size (bp)
1287 bp
Protein Name (eCommerce)
ETS domain-containing protein Elk-1
RefSeq ID
NM_005229
RefSeq Synonyms
NM_005229, NM_001257168, NM_001114123, BC056150,
Research Areas
Angiogenesis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiovascular,EGFR Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,GnRH Signaling,HGF Signaling,Host-Virus Interactions,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Leptin Signaling,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,Prolactin Signaling,Prostate Cancer,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,TPO Signaling,Transcription Factor/Regulator,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade [taken from NCBI Entrez Gene (Gene ID: 2002)].
UniGene ID
Hs.181128
UniProt ID (eCommerce)
P19419

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.