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human ELK1 shRNA silencing AAV

Name 
AAV-h-ELK1-shRNA
Cat No 
shAAV-207840
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ELK1.

shAAV-207840
AAV-h-ELK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ELK1 (ELK1, ETS transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1) oncogene
Description (eCommerce)
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade [taken from NCBI Entrez Gene (Gene ID: 2002)].
Description (Vector)
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. ELK1 produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
Gene ID
2002
Gene Name (eCommerce)
ELK1, ETS transcription factor
Gene Name (Vector)
ELK1, ETS transcription factor
Gene Symbol
ELK1
HGNC ID
HGNC:3321
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1287
ORF Size (bp)
1287 bp
Protein Name (eCommerce)
ETS domain-containing protein Elk-1
RefSeq ID
NM_005229
RefSeq Synonyms
NM_005229, NM_001257168, NM_001114123, BC056150,
Research Areas
Angiogenesis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiovascular,EGFR Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,GnRH Signaling,HGF Signaling,Host-Virus Interactions,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Leptin Signaling,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,Prolactin Signaling,Prostate Cancer,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,TPO Signaling,Transcription Factor/Regulator,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
ELK1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade [taken from NCBI Entrez Gene (Gene ID: 2002)].
UniGene ID
Hs.181128
UniProt ID (eCommerce)
P19419

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.