human MBTPS1 shRNA silencing AAV

Name
AAV-h-MBTPS1-shRNA

Cat No
shAAV-215128

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MBTPS1.

shAAV-215128

AAV-h-MBTPS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MBTPS1 (membrane bound transcription factor peptidase, site 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PCSK8; S1P; SKI-1

Description (Vector)

The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein.

Gene ID

8720

Gene Name (Vector)

membrane bound transcription factor peptidase, site 1

Gene Symbol

MBTPS1

HGNC ID

HGNC:15456

ORF Size (aa)

3159

ORF Size (bp)

3159 bp

RefSeq ID

NM_003791

RefSeq Synonyms

NM_003791, BC114961, BC114555, BC026330,

Species

human

UniGene ID

Hs.75890

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.