human MAN1B1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAN1B1.
shAAV-214875
AAV-h-MAN1B1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAN1B1 (mannosidase alpha class 1B member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ERMAN1; ERManI; MANA-ER; MRT15
Description (Vector)
MAN1B1 encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.
Gene ID
11253
Gene Name (Vector)
mannosidase alpha class 1B member 1
Gene Symbol
MAN1B1
HGNC ID
HGNC:6823
ORF Size (aa)
2100
ORF Size (bp)
2100 bp
RefSeq ID
NM_016219
RefSeq Synonyms
NM_016219, BC006079, BC002953,
Species
human
UniGene ID
Hs.279881
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.