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human MAN1B1 Adenovirus

Name 
Ad-h-MAN1B1
Cat No 
ADV-214875
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MAN1B1.

ADV-214875
Ad-h-MAN1B1

Ready-to-use Adenovirus expressing Human MAN1B1 (mannosidase alpha class 1B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ERMAN1; ERManI; MANA-ER; MRT15
Description (Vector)
MAN1B1 encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.
Gene ID
11253
Gene Name (Vector)
mannosidase alpha class 1B member 1
Gene Symbol
MAN1B1
HGNC ID
HGNC:6823
ORF Size (aa)
2100
ORF Size (bp)
2100 bp
RefSeq ID
NM_016219
RefSeq Synonyms
NM_016219, BC006079, BC002953,
Species
human
UniGene ID
Hs.279881

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.