human KPNA6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KPNA6.
shAAV-213349
AAV-h-KPNA6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KPNA6 (karyopherin subunit alpha 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IPOA7; KPNA7
Description (Vector)
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.
Gene ID
23633
Gene Name (Vector)
karyopherin subunit alpha 6
Gene Symbol
KPNA6
HGNC ID
HGNC:6399
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
RefSeq ID
NM_012316
RefSeq Synonyms
NM_012316, BC020520,
Species
human
UniGene ID
Hs.711019
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.