human ITGAV shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ITGAV.
shAAV-212497
AAV-h-ITGAV-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ITGAV (integrin subunit alpha V). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD51; MSK8; VNRA; VTNR
Description (Vector)
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants.
Gene ID
3685
Gene Name (Vector)
integrin subunit alpha V
Gene Symbol
ITGAV
HGNC ID
HGNC:6150
ORF Size (aa)
3039
ORF Size (bp)
3039 bp
RefSeq ID
NM_002210
RefSeq Synonyms
NM_002210, NM_001145000, NM_001144999, BC144100, BC136442, BC126231,
Species
human
UniGene ID
Hs.436873
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.