mouse IRF5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Irf5.
shAAV-262371
AAV-m-IRF5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Irf5 (interferon regulatory factor 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW491843; interferon regulatory factor 5; interferon regulatory factor 5 bone marrow; IRF-5; mirf5
Description (eCommerce)
Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF5 binds to the VRE of IFN- a genes. Mutations in human IRF5 result in a predisposition to autoimmune disease.
Description (Vector)
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.
Gene ID
27056
Gene Name (eCommerce)
interferon regulatory factor 5
Gene Name (Vector)
interferon regulatory factor 5
Gene Symbol
Irf5
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1494
ORF Size (bp)
1494 bp
Protein Name (eCommerce)
Interferon regulatory factor 5
RefSeq ID
NM_012057
RefSeq Synonyms
NM_012057, NM_001311083, NM_001252382, BC160276,
Research Areas
Apoptosis,Host-Virus Interactions,Immunology,Innate Immunity,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction,transcription_translation
Species
mouse
Target Sentence
Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF5 binds to the VRE of IFN- a genes. Mutations in human IRF5 result in a predisposition to autoimmune disease.
UniGene ID
Mm.6479
UniProt ID (eCommerce)
P56477
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.