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human GPX4 shRNA silencing AAV

Name 
AAV-h-GPX4-shRNA
Cat No 
shAAV-210463
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GPX4.

shAAV-210463
AAV-h-GPX4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPX4 (glutathione peroxidase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GPx-4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx
Description (Vector)
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.
Gene ID
2879
Gene Name (Vector)
glutathione peroxidase 4
Gene Symbol
GPX4
HGNC ID
HGNC:4556
ORF Size (aa)
594
RefSeq ID
NM_002085
RefSeq Synonyms
NM_002085, NM_001039848, NM_001039847, BC046163, BC039849, BC032695, BC022071, BC021567, BC011836, BC010157,
Species
human
UniGene ID
Hs.433951

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.