human DIS3L2 Over-expression AAV

Name 
AAV-h-DIS3L2
Cat No 
AAV-207011
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DIS3L2.

AAV-207011
AAV-h-DIS3L2

Ready-to-use AAV expressing Human DIS3L2 (DIS3 like 3′-5′ exoribonuclease 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2; FAM6A; family with sequence similarity 6, member A; hDIS3L2; PRLMNS
Description (eCommerce)
DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7].
Description (Vector)
DIS3L2 is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.
Gene ID
129563
Gene Name (eCommerce)
DIS3 like 3'-5' exoribonuclease 2
Gene Name (Vector)
DIS3 like 3'-5' exoribonuclease 2
Gene Symbol
DIS3L2
HGNC ID
HGNC:28648
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1860
ORF Size (bp)
1860 bp
Protein Name (eCommerce)
DIS3-like exonuclease 2
RefSeq ID
NM_152383
RefSeq Synonyms
NM_152383, NM_001257282, NM_001257281, BC036113, BC026166,
Research Areas
Cancer,Cell Cycle,Cell Division,RNA Binding,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7].
UniGene ID
Hs.471637
UniProt ID (eCommerce)
Q8IYB7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.