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human DIS3L2 shRNA silencing Adenovirus

Name 
Ad-h-DIS3L2-shRNA
Cat No 
shADV-207011
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DIS3L2.

shADV-207011
Ad-h-DIS3L2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DIS3L2 (DIS3 like 3′-5′ exoribonuclease 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2; FAM6A; family with sequence similarity 6, member A; hDIS3L2; PRLMNS
Description (eCommerce)
DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7].
Description (Vector)
DIS3L2 is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.
Gene ID
129563
Gene Name (eCommerce)
DIS3 like 3'-5' exoribonuclease 2
Gene Name (Vector)
DIS3 like 3'-5' exoribonuclease 2
Gene Symbol
DIS3L2
HGNC ID
HGNC:28648
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1860
ORF Size (bp)
1860 bp
Protein Name (eCommerce)
DIS3-like exonuclease 2
RefSeq ID
NM_152383
RefSeq Synonyms
NM_152383, NM_001257282, NM_001257281, BC036113, BC026166,
Research Areas
Cancer,Cell Cycle,Cell Division,RNA Binding,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7].
UniGene ID
Hs.471637
UniProt ID (eCommerce)
Q8IYB7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.