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human CLCN4 shRNA silencing AAV

Name 
AAV-h-CLCN4-shRNA
Cat No 
shAAV-205352
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CLCN4.

shAAV-205352
AAV-h-CLCN4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLCN4 (chloride voltage-gated channel 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ClC-4; ClC-4A; CLC4; MRX15; MRX49
Description (Vector)
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
Gene ID
1183
Gene Name (Vector)
chloride voltage-gated channel 4
Gene Symbol
CLCN4
HGNC ID
HGNC:2022
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
RefSeq ID
NM_001830
RefSeq Synonyms
NM_001830, NM_001256944, BC130278, BC036068,
Species
human
UniGene ID
Hs.495674

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.