human CD48 shRNA silencing AAV

Name 
AAV-h-CD48-shRNA
Cat No 
shAAV-204662
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CD48.

shAAV-204662
AAV-h-CD48-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD48 (CD48 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BCM1;BCM1 surface antigen;BLAST;BLAST1;B-lymphocyte activation marker BLAST-1;CD antigen CD48;CD48 antigen;CD48 antigen (B-cell membrane protein);hCD48;leukocyte antigen MEM-102;mCD48;MEM-102;signaling lymphocytic activation molecule 2;SLAM family member 2;SLAMF2;TCT.1
Description (eCommerce)
CD48 is a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. CD48 does not have a transmembrane domain, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor [taken from NCBI Entrez Gene (Gene ID: 962)].
Description (Vector)
CD48 encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
962
Gene Name (eCommerce)
CD48 molecule
Gene Name (Vector)
CD48 molecule
Gene Symbol
CD48
HGNC ID
HGNC:1683
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
732
ORF Size (bp)
732 bp
Protein Name (eCommerce)
CD48 antigen
RefSeq ID
NM_001778
RefSeq Synonyms
NM_001778, NM_001256030, BC030224, BC016182,
Research Areas
Cancer,Cardiovascular,Immunology,Signal Transduction
Research Areas (Faceted)
cardiovascular,cancer,signal_transduction,immunology
Species
human
Target Sentence
CD48 is a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. CD48 does not have a transmembrane domain, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor [taken from NCBI Entrez Gene (Gene ID: 962)].
UniGene ID
Hs.243564
UniProt ID (eCommerce)
P09326

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.