human CBX4 shRNA silencing AAV

Name 
AAV-h-CBX4-shRNA
Cat No 
shAAV-204199
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CBX4.

shAAV-204199
AAV-h-CBX4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CBX4 (chromobox 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; polycomb 2 homolog
Description (eCommerce)
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
Gene ID
8535
Gene Name (eCommerce)
chromobox 4
Gene Name (Vector)
chromobox 4
Gene Symbol
CBX4
HGNC ID
HGNC:1554
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
873
ORF Size (bp)
873 bp
Protein Name (eCommerce)
E3 SUMO-protein ligase CBX4
RefSeq ID
NM_003655
RefSeq Synonyms
NM_003655, BC014967,
Research Areas
Apoptosis,Chromatin Remodeling,Complexome,Golgi Apparatus,Polycomb Proteins,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
UniGene ID
Hs.714363
UniProt ID (eCommerce)
O00257

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.