rat TRIM72 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Trim72.
shADV-295122
Ad-r-TRIM72-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Trim72 (tripartite motif containing 72). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGD1562778
Description (Vector)
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Gene ID
365377
Gene Name (Vector)
tripartite motif containing 72
Gene Symbol
Trim72
ORF Size (aa)
1434
ORF Size (bp)
1434 bp
RefSeq ID
NM_001077675
RefSeq Synonyms
NM_001077675, BC127539,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.