rat RGD1565983 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Apex2.
shADV-295121
Ad-r-RGD1565983-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Apex2 (apurinic/apyrimidinic endodeoxyribonuclease 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
Gene ID
317628
Gene Name (Vector)
apurinic/apyrimidinic endodeoxyribonuclease 2
Gene Symbol
Apex2
ORF Size (aa)
1551
ORF Size (bp)
1551 bp
RefSeq ID
NM_001079892
RefSeq Synonyms
NM_001079892, BC127530,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.