rat OLDLR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Olr1.
shADV-293920
Ad-r-OLDLR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Olr1 (oxidized low density lipoprotein (lectin-like) receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LOX-1; Oldlr1; Oldr1
Description (Vector)
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Gene ID
140914
Gene Name (Vector)
oxidized low density lipoprotein (lectin-like) receptor 1
Gene Symbol
Olr1
ORF Size (aa)
1095
ORF Size (bp)
1095 bp
RefSeq ID
NM_133306
RefSeq Synonyms
NM_133306, BC097290,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.