rat PVR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat PVR.
shADV-293801
Ad-r-PVR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat PVR (poliovirus receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Taa1; Tage4
Description (Vector)
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Gene ID
25066
Gene Name (Vector)
poliovirus receptor
Gene Symbol
PVR
ORF Size (aa)
1239
ORF Size (bp)
1239 bp
RefSeq ID
NM_017076
RefSeq Synonyms
NM_017076, BC085741,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.