rat STAT2 shRNA silencing Adenovirus

Name
Ad-r-STAT2-shRNA

Cat No
shADV-293632

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Stat2.

shADV-293632

Ad-r-STAT2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Stat2 (signal transducer and activator of transcription 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Gene ID

288774

Gene Name (Vector)

signal transducer and activator of transcription 2

Gene Symbol

Stat2

ORF Size (aa)

2529

ORF Size (bp)

2529 bp

RefSeq ID

NM_001011905

RefSeq Synonyms

NM_001011905, BC083867,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.