rat TXNIP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Txnip.
shADV-292998
Ad-r-TXNIP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Txnip (thioredoxin interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Vdup1
Description (Vector)
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Gene ID
117514
Gene Name (Vector)
thioredoxin interacting protein
Gene Symbol
Txnip
ORF Size (aa)
1185
RefSeq ID
NM_001008767
RefSeq Synonyms
NM_001008767, BC088411,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.