rat IRF9 shRNA silencing Adenovirus

Name
Ad-r-IRF9-shRNA

Cat No
shADV-292021

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Irf9.

shADV-292021

Ad-r-IRF9-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Irf9 (interferon regulatory factor 9). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Isgf3g

Description (Vector)

Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Gene ID

305896

Gene Name (Vector)

interferon regulatory factor 9

Gene Symbol

Irf9

ORF Size (aa)

1197

RefSeq ID

NM_001012041

RefSeq Synonyms

NM_001012041, BC079454,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.