rat TP53 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Tp53.
shADV-291615
Ad-r-TP53-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Tp53 (tumor protein p53). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p53; Trp53
Description (Vector)
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Gene ID
24842
Gene Name (Vector)
tumor protein p53
Gene Symbol
Tp53
ORF Size (aa)
1176
ORF Size (bp)
1176 bp
RefSeq ID
NM_030989
RefSeq Synonyms
NM_030989, BC098663, BC081788,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.